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Anti-tfrc Antibody (CAT#: MOM-18319)

Datasheet
DESCRIPTION CATALOG # SIZE PRICE
Recombinant Anti-Human tfrc Antibody MOM-18319 1mg Please Inquiry

PRODUCT INFORMATION

  • Product Overview
  • Recombinant Mouse Antibody is specific to Human TFRC, expressed in Chinese Hamster Ovary cells(CHO)
  • Target
  • TFRC
  • Type
  • IgG
  • Immunogen
  • Tissue / cell preparation (Human). (KG1 acute myelogenous leukaemia cell line).
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Applications
  • Suitable for use in WB, ELISA, IP, FC, FuncS, Neut and most other immunological methods.
  • Specific Activity
  • Tested positive against native antigen.
  • Purity
  • >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.
  • Storage
  • Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C.

BACKGROUND

  • Antigen Description
  • Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
  • Function
  • Hsp70 protein binding; chaperone binding; peptidase activity; receptor activity; transferrin receptor activity;
  • Synonyms
  • TFRC; transferrin receptor (p90, CD71); transferrin receptor protein 1; CD71; TFR1; T9; TR; TFR; p90; TRFR

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